期刊
CARBOHYDRATE POLYMERS
卷 178, 期 -, 页码 394-405出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.08.120
关键词
Bacterial cellulose; Chitosan; Heparinization; Artificial blood vessels; 3D surface structure and roughness; Hemocompatibility and cytocompatibility
资金
- National Natural Science Foundation of China [51373031]
- Science and Technology Commission of Shanghai Municipality [15520720800]
- 111 Project [B07024]
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) [LK1617]
- Fundamental Research Funds for the Central Universities
In order to improve property of bacterial nano-cellulose (BNC) to achieve the requirements of clinical application as small caliber vascular grafts, chitosan (CH) was deposited into the fibril network of the BNC tubes fabricated in unique Double-Silicone-Tube bioreactors. Heparin (Hep) was then chemically grafted into the BNC-based tubes using EDC/NHS crosslinking to improve performance of anticoagulation and endothelialization. Physicochemical and mechanical property, blood compatibility, and cytocompatibility were compared before and after compositing. The results indicated that strength at break was increased but burst pressure decreased slightly after compositing. Performance of the BNC tubes was improved remarkably after introducing chitosan and heparin. The EDC/NHS crosslinking catalyzed both amide bonds and ester bonds formation in the BNC/CH-Hep composites. Three-dimensional surface structure and roughness were firstly obtained and discussed in relation to the hemocompatibility of BNC-based tubes. This work demonstrates the heparinized BNC-based tubes have great potential in application as small-diameter vascular prosthesis.
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