期刊
TOXICOLOGY
卷 392, 期 -, 页码 47-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2017.10.006
关键词
Nickel; Neurotoxicity; Mitochondria dysfunction; Antioxidants; Neuroprotective effect; Chemoprevention
资金
- National Nature Science Foundation of China [81273111]
- Scientific Projects of Zhejiang Province [2015C33148, 2015C37117]
- Foundations of Innovative Research Team of Educational Commission of Zhejiang Province [T200907]
- Ningbo Scientific Innovation Team for Environmental Hazardous Factor Control and Prevention [2016C51001]
- Zhejiang Key Laboratory of Pathophysiology [201703]
- KC Wong Magna Fund in Ningbo University
Nickel (Ni) is widely used in many industrial sectors such as alloy, welding, printing inks, electrical and electronics industries. Excessive environmental or occupational exposure to Ni may result in tumor, contact dermatitis, as well as damages to the nervous system. In recent years, more and more research has demonstrated that Ni induced nerve damages are related to mitochondrial dysfunction. In this paper, we try to characterize Ni induced neurotoxicity as well as the underlying mechanisms, and how to find new drugs for chemoprevention, by reviewing chemicals with neuroprotective effects on Ni induced neurotoxicity.
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