相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。FABP4 inhibition suppresses PPARγ activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages
Marcel Boss et al.
ATHEROSCLEROSIS (2015)
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
Sandra March et al.
NATURE PROTOCOLS (2015)
Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
Theresa V. Nguyen et al.
DRUG METABOLISM AND DISPOSITION (2015)
Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide
Lisbeth K. Siddens et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
K. Yang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Patricio Godoy et al.
ARCHIVES OF TOXICOLOGY (2013)
Transporter Studies in Drug Development: Experience to Date and Follow-Up on Decision Trees From the International Transporter Consortium
D. Tweedie et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans
Salman R. Khetani et al.
TOXICOLOGICAL SCIENCES (2013)
Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
Tom S. Chan et al.
DRUG METABOLISM AND DISPOSITION (2013)
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
H. H. J. Gerets et al.
CELL BIOLOGY AND TOXICOLOGY (2012)
Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?
Min Zhang et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2012)
Compilation of 222 drugs' plasma protein binding data and guidance for study designs
Fengling Zhang et al.
DRUG DISCOVERY TODAY (2012)
Complement Activation in Acetaminophen-Induced Liver Injury in Mice
Rohit Singhal et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Luciferin IPA-Based Higher Throughput Human Hepatocyte Screening Assays for CYP3A4 Inhibition and Induction
Utkarsh Doshi et al.
JOURNAL OF BIOMOLECULAR SCREENING (2011)
In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury
Toru Usui et al.
DRUG METABOLISM AND DISPOSITION (2011)
Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
Wendy WeiWei Wang et al.
DRUG METABOLISM AND DISPOSITION (2010)
A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
Anne S. Kienhuis et al.
TOXICOLOGY IN VITRO (2009)
Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans
T. Uehara et al.
HUMAN & EXPERIMENTAL TOXICOLOGY (2008)
Cellular imaging predictions of clinical drug-induced liver injury
Jinghai J. Xu et al.
TOXICOLOGICAL SCIENCES (2008)
Idiosyncratic drug hepatotoxicity
N Kaplowitz
NATURE REVIEWS DRUG DISCOVERY (2005)
Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
AJ Harris et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2004)
Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro
LD Kier et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2004)
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission
K Kassahun et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Concordance of the toxicity of pharmaceuticals in humans and in animals
H Olson et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2000)