期刊
TOXICOLOGIC PATHOLOGY
卷 46, 期 1, 页码 47-61出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623317737254
关键词
bioprocessing; ions; liver; nanoceria; nanoparticles; spleen; transformation
资金
- U.S. Environmental Protection Agency Science to Achieve Results [RD-833772]
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM109195]
- United States Environmental Protection Agency through STAR [RD-833772]
This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure. These advanced analytical electron microscopy methods were applied to elucidate the organ-specific cellular and subcellular fate of nanoceria after its uptake. Nanoceria is bioprocessed differently in the spleen than in the liver.
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