期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 51, 页码 16308-16312出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710537
关键词
amines; amino alcohols; arylation; atroposelectivity; organocatalysis
资金
- National Natural Science Foundation of China [21572095, 21772081]
- Shenzhen special funds for the development of biomedicine, internet, new energy, and new material industries [JCYJ20170412151701379]
The first phosphoric acid catalyzed direct arylation of 2-naphthylamines with iminoquinones for the atroposelective synthesis of axially chiral biaryl amino alcohols has been developed. This reaction constitutes a highly functional-group-tolerant route for the rapid construction of enantioenriched axially chiral biaryl amino alcohols, and is a rare example of 2-naphthylamines acting as nucleophiles in an organocatalytic enantioselective transformation. Furthermore, the products, which feature various halogen atoms, provide access to structurally diverse axially chiral amino alcohols through further transformations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据