期刊
CHEMMEDCHEM
卷 12, 期 24, 页码 2016-2021出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201700512
关键词
azobenzene; DNA; drug release; microcapsules; photo-trigger
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [24104005, 26102518, 16H00762, 16K12522]
- JSPS A3 Foresight Program
- Grants-in-Aid for Scientific Research [15H03838, 16H00762, 16K12522] Funding Source: KAKEN
In this study we constructed spherical photo-responsive microcapsules composed of three photo-switchable DNA strands. These strands first formed a three-way junction (TWJ) motif that further self-assembled to form microspheres through hybridization of the sticky-end regions of each branch. To serve as the photo-switch, multiple unmodified azobenzene (Azo) or 2,6-dimethyl-4-(methylthio)azobenzene (SDM-Azo) were introduced into the sticky-end regions via a d-threoninol linker. The DNA capsule structure deformed upon trans-to-cis isomerization of Azo or SDM-Azo induced by specific light irradiation. In addition, photo-triggered release of encapsulated small molecules from the DNA microcapsule was successfully achieved. Moreover, we demonstrated that photo-triggered release of doxorubicin caused cytotoxicity to cultured cells. This biocompatible photo-responsive microcapsule has potential application as a photo-controlled drug-release system.
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