期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 4, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2017.00080
关键词
monocytes; patrolling; arteriosclerosis; arteries; microcirculation; venules
资金
- National Institutes of Health [R01 HL115232]
- Deutsche Forschungsgemeinschaft [BU-3247]
Non-classical monocytes have emerged as the preeminent vascular housekeepers. Continuous intravascular screening is enabled by slow patrolling on the endothelium and allows a rapid response to local perturbations. Intravital imaging has been crucial to elucidate the molecular mechanisms and migratory phenotype of patrolling. In this review, we discuss technical requirements of intravital microscopy such as imaging modalities, labeling strategies, and data analysis. We further focus on patrolling kinetics and adhesion receptors in different organs and vascular beds including arteries during homeostasis and vascular inflammation and define pertinent questions in the field.
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