4.5 Article

Yeast cell fractionation by morphology in dilute ferrofluids

期刊

BIOMICROFLUIDICS
卷 11, 期 6, 页码 -

出版社

AIP Publishing
DOI: 10.1063/1.5006445

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资金

  1. China Scholarship Council (CSC)-Chinese Government Graduate Student Overseas Study Program
  2. NIH [1R15 AI119801-01]
  3. NSF [CBET-1150670]
  4. Directorate For Engineering
  5. Div Of Chem, Bioeng, Env, & Transp Sys [1150670] Funding Source: National Science Foundation

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Morphology is an important particle (both biological and synthetic) property and potentially a useful marker for label-free particle separation. We present in this work a continuous-flow morphology-based fractionation of a heterogeneous mixture of drug-treated yeast cells in dilute ferrofluids. Such a diamagnetic cell separation technique utilizes the negative magnetophoretic motion to direct pre-focused yeast cells to morphology-dependent streamlines in a laminar flow. The separation performance is evaluated by comparing the exiting positions of the four classified groups of yeast cells: Singles, Doubles, Triples, and Others. We also develop a three-dimensional numerical model to simulate the separation process by the use of the experimentally determined correction factor for each group of non-spherical cells. The determining factors in this separation are studied both experimentally and numerically, the results of which show a reasonable agreement. Published by AIP Publishing.

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