期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 50, 页码 43449-43458出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b13602
关键词
nanocomposites; hydrogels; 3D bioprinting; two-dimensional (2D) nanoparticles; bioinks
资金
- National Institute Of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) [DP2EB026265, R03EB02345]
- National Science Foundation (NSF) [CBET 1705852]
Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress because of the lack of suitable bioinks that are printable, have high shape fidelity, and are mechanically resilient. In this study, we introduce a new family of nanoengineered bioinks consisting of kappa-carrageenan (kappa CA) and two-dimensional (2D) nanosilicates (nSi). kappa CA is a biocompatible, linear, sulfated polysaccharide derived from red algae and can undergo thermo-reversible and ionic gelation. The shear-thinning characteristics of kappa CA were tailored by nanosilicates to develop a printable bioink. By tuning kappa CA-nanosilicate ratios, the thermo-reversible gelation of the bioink can be controlled to obtain high printability and shape retention characteristics. The unique aspect of the nanoengineered kappa CA-nSi bioink is its ability to print physiologically-relevant-scale tissue constructs without requiring secondary supports. We envision that nanoengineered kappa CA-nanosilicate bioinks can be used to 3D print complex, large-scale, cell-laden tissue constructs with high structural fidelity and tunable mechanical stiffness for regenerative medicine.
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