期刊
BIO-PROTOCOL
卷 7, 期 24, 页码 -出版社
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.2646
关键词
xCELLigence; Real-time cell analysis; Cell adhesion; Extracellular matrix; Integrins
类别
资金
- Academy of Finland
- ERC Consolidator Grant [615258]
- Sigrid Juselius Foundation
- Finnish Cancer Organization
- Turku Doctoral Programme of Molecular Medicine (TuDMM)
- European Research Council (ERC) [615258] Funding Source: European Research Council (ERC)
Cell adhesion to neighbouring cells and to the underlying extracellular matrix (ECM) is a fundamental requirement for the existence of multicellular organisms. As such, the formation, stability and dissociation of cell adhesions are subject to tight control in space and time and perturbations within the sophisticated adhesion machinery are associated with a variety of human pathologies. Here, we outline a simple protocol to monitor alterations in cell adhesion to the ECM, for example, following genetic manipulations or overexpression of a protein of interest or in response to drug treatment, using the xCELLigence real-time cell analysis (RTCA) system.
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