期刊
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 83, 期 9, 页码 1991-1999出版社
WILEY
DOI: 10.1111/bcp.13301
关键词
age; blood-brain barrier; drug-drug interaction; PET; P-glycoprotein
资金
- Austrian Science Fund (FWF) [F 3513-B20, KLI 480-B30]
AIMS The efflux transporter P-glycoprotein (ABCB1) acts at the blood-brain barrier (BBB) to restrict the distribution of many different drugs from blood to the brain. Previous data suggest an age-associated decrease in the expression and function of ABCB1 at the BBB. In the present study, we investigated the influence of age on the magnitude of an ABCB1-mediated drug-drug interaction (DDI) at the BBB. METHODS We performed positron emission tomography scans using the model ABCB1 substrate (R)-[C-11] verapamil in five young [26 +/- 1 years, (mean +/- standard deviation)] and five elderly (68 +/- 6 years) healthy male volunteers before and after intravenous administration of a low dose of the ABCB1 inhibitor tariquidar (3 mg kg(-1)). RESULTS In baseline scans, the total distribution volume (VT) of (R)-[C-11] verapamil in whole-brain grey matter was not significantly different between the elderly (VT = 0.78 +/- 0.15) and young (VT = 0.79 +/- 0.10) group. After partial (incomplete) ABCB1 inhibition, VT values were significantly higher (P = 0.040) in the elderly (VT = 1.08 +/- 0.15) than in the young (VT = 0.80 +/- 0.18) group. The percentage increase in (R)-[C-11] verapamil VT following partial ABCB1 inhibition was significantly greater (P = 0.032) in elderly (+40 +/- 17%) than in young (+2 +/- 17%) volunteers. Tariquidar plasma concentrations were not significantly different between the young (786 +/- 178 nmol l(-1)) and elderly (1116 +/- 347 nmol l(-1)) group. CONCLUSIONS Our results provide the first direct evidence of an increased risk for ABCB1-mediated DDIs at the BBB in elderly persons, which may have important consequences for pharmacotherapy of the elderly.
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