期刊
THROMBOSIS AND HAEMOSTASIS
卷 117, 期 3, 页码 437-444出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH16-08-0620
关键词
Heparin; coagulation; inflammation
资金
- BIO2 Medical
- Boehringer-Ingelheim
- Bristol-Myers Squibb
- BTG EKOS
- Daiichi Sankyo
- National Heart, Lung, and Blood Institute of the National Institutes of Health
- Janssen
- Thrombosis Research Institute
- Bayer
- Novartis
- Portola
The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases. This review focuses on the inflammatory pathophysiology that underlies the development of thrombosis and the putative effects of heparin on these pathways. We present evidence supporting the use of heparin for other indications, including autoimmune disease, malignancy, and disseminated intravascular coagulation. These considerations highlight the need for further research to elucidate the mechanisms of the possible pleiotropic effects of the heparins, with a view to advancing treatments based upon heparin derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据