期刊
THROMBOSIS AND HAEMOSTASIS
卷 117, 期 7, 页码 1296-1316出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH16-12-0943
关键词
Atherothrombosis; cell-cell interactions; inflammatory mediators; macrophage
资金
- Swiss National Foundation for Scientific Research [310030_153436, 310030_166357]
- Spanish Ministry of Science, Plan Estatal I+D+I [SAF2013-42962-R]
- TerCel (Red de Terapia Celular) [RD/12/0019/0026]
- Canadian Institutes of Health Research
- Agence Nationale pour la Recherche [ANR-11-IDEX-05-02]
- National Institute for Health and Medical Research (INSERM)
- National Agency for Research [ANR-2011-META-miRA, ANR-2016-Cardinal]
- Fondation de France [Engt-2012-00029497]
- OTKA [120237, 111958]
- MEDINPROT
- NVKP_16 (National Heart Program)
- British Heart Foundation [FS/11/52/29018, RG/13/1/30042, PG14/38/30862, FS/14/8/30605]
- Aix Marseille University (AMU)
- Amidex * (AAP Emergence VINTAGE)
- Swedish Heart-Lung Foundation
- Karolinska Institute
- Deutsche Forschungsgemeinschaft [SFB1123-A5, SFB1123-Al/B4]
- European Research Council (ERC) [Con o681493, AdG o692511]
- Netherlands Organisation for Scientific Research (NWO) (VICI)
- Swiss National Science Foundation (SNF) [310030_153436] Funding Source: Swiss National Science Foundation (SNF)
- British Heart Foundation [FS/14/8/30605, PG/16/58/32275, RG/13/1/30042, PG/14/38/30862, FS/11/52/29018] Funding Source: researchfish
Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as microparticles. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microve-sicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.
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