期刊
THROMBOSIS AND HAEMOSTASIS
卷 117, 期 2, 页码 246-251出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH16-07-0588
关键词
Embolism; thrombolysis; (intracranial) haemorrhage
资金
- Bristol-Myers Squibb/Pfizer
- Blue Cross-Blue Shield of Michigan
- Portola Pharmaceuticals
- Diagnostica Stago
- Siemens Healthcare
- Janssen Pharmaceuticals
- Boehringer-Ingelheim
- American College of Cardiology
- Actelion
- Gilead Lifesciences
- Bayer
- United Therapeutics
Pulmonary embolism (PE) is a major cause of morbidity and mortality world-wide, and the use of thrombolytic therapy has been associated with favourable clinical outcomes in certain patient subsets. These potential benefits are counterbalanced by the risk of bleeding complications, the most devastating of which is intracranial haemorrhage (ICH). We retrospectively evaluated 9703 patients from the 2003-2012 nationwide in-patient sample database (NIS) who received thrombolytics for PE. All patients with ICH during the PE hospitalisation were identified and a clinical risk score model was developed utilizing demographics and comorbidities. The dataset was divided 1:1 into derivation and validation cohorts. During 2003-2012, 176/9705 (1.8 %) patients with PE experienced ICH after thrombolytic use. Four independent prognostic factors were identified in a backward logistic regression model, and each was assigned a number of points proportional to its regression coefficient: pre-existing Peripheral vascular disease (1 point), age greater than 65 years (Elderly) (1 point), prior Cerebrovascular accident with residual deficit (5 points), and prior myocardial infarction (Heart attack) (1 point). In the derivation cohort, scores of 0, 1, 2 and 5 points were associated with ICH risks of 1.2 %,1.9 %, 2.4 % and 17.8 %, respectively. Rates of ICH were similar in the validation cohort. The C-statistic for the risk score was 0.65 (0.61-0.70) in the derivation cohort and 0.66 (0.60-0.72) in the validation cohort. A novel risk score, derived from simple clinical historical elements was developed to predict ICH in PE patients treated with thrombolytics.
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