期刊
THORAX
卷 72, 期 11, 页码 1052-1054出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2016-209897
关键词
-
资金
- OneLegacy foundation
- Nina Ireland Program for Lung Health, VA [1IK2CX001034-01A2]
- National Heart, Lung and Blood Institute [P01HL108794, 5T32HL007185-37]
Telomere length (TL) decreases with cellular ageing and biological stressors. As advanced donor and recipient ages are risk factors for chronic lung allograft dysfunction (CLAD), we hypothesised that decreased age-adjusted donor TL would predict earlier onset of CLAD. Shorter donor TL was associated with increased risk of CLAD or death (HR 1.26 per 1 kb TL decrease, 95% CI 1.03 to 1.54), particularly for young donors. Recipient TL was associated with cytopenias but not CLAD. Shorter TL was also seen in airway epithelium for subjects progressing to CLAD (p=0.02). Allograft TL may contribute to CLAD pathogenesis and facilitate risk stratification.
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