期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 48, 页码 42225-42238出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14796
关键词
nanocolloidosomes; selective drug release; hydroxyethyl starch; active targeting; photothermal/chemo combination therapy
资金
- National Basic Research Program of China [2015CB931802]
- National Science Foundation of China [81627901, 81473171, 31700867]
- PCSIRT [IRT13016]
- Scientific Research Foundation of Huazhong University of Science and Technology [3004170130]
Selective drug release is highly desirable for photothermal/chemo combination therapy when two or even more theranostic agents are encapsulated together within the same nanocarrier. A conventional nanocarrier can hardly achieve this goal. Herein, doxorubicin and indocyanine green (DOX/ICG)-loaded nanocolloidosomes (NCs), with selective drug release, were fabricated as a novel multifunctional theranostic nanoplatform for photothermal/chemo combination therapy. Templating from galactose-functionalized hydroxyethyl starch-polycaprolactone (Gal-HES-PCL) nanoparticles-stabilized Pickering emulsions, the resultant DOX/ICG@Gal-HES-PCL NCs had a diameter of around 140 nm and showed an outstanding tumor-targeting ability, preferable tumor penetration capability, and promotion of photothermal effect. Moreover, these NCs can be used for NIR fluorescence imaging and thus render real-time imaging of solid tumors with high contrast. Collectively, such NCs achieved the best in vivo antitumor efficacy combined with laser irradiation compared with DOX/ICG@HES-PCL NCs and DOX/ICG mixture. These NCs are valuable for active tumor-targeted imaging-guided combination therapy against liver cancer and potentially other diseases.
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