期刊
TETRAHEDRON LETTERS
卷 58, 期 25, 页码 2507-2511出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.05.059
关键词
Visconata; Odd numbered long chain fatty acid; Dodonaea viscosa; Novel flavonol; Human neutrophil elastase (HNE)
资金
- Ministry of Agriculture, Food and Rural Affairs, Republic of Korea [315032-04-2-SB010]
- Ministry of Education, through (NRF), Republic of Korea [2015R1A6A1A03031413]
- BK21 plus program
A series of flavonoids were isolated from Dodonaea Viscosa and tested for inhibition of human neutrophil elastase (HNE), enzyme involved in inflammatory disorders. Isolated compounds were identified as a novel flavonol (1) along with eight known flavonoids (2-9). Novel flavonol, visconata (1) has a very rare skeleton having odd numbered long chain (C19) fatty acid, which was completely identified by mass fragmentation and 2D NMR analysis. All compounds (1-9) inhibited HNE in dose dependent manner with IC(50)s ranging between 2.4 and 150 mu M. Visconata (1) emerged to be the most potent compound with 2.4 mu M of IC50. In kinetic studies, compound (1) was observed to be reversible, noncompetitive inhibitor having K, = 1.8 mu M, whereas other flavonoids (2-9) displayed mixed type inhibition. (C) 2017 Elsevier Ltd. All rights reserved.
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