期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 12, 期 24, 页码 3123-3127出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201701530
关键词
alkynes; cross-coupling; cyclization; hypervalent compounds; iodine
资金
- Singapore Ministry of Education and Nanyang Technological University [RG3/15, RG114/15, MOE2016-T2-2-043]
The utility of benziodoxole triflate, derived from ,-bis(trifluoromethyl)-2-iodobenzyl alcohol, as a versatile reagent for iodo(III)cyclization via electrophilic activation of alkyne, is reported herein. The reagent promotes cyclization of alkynes tethered to a variety of nucleophilic moieties, affording benziodoxole-appended (hetero)arenes such as benzofurans, benzothiophenes, isocoumarins, indoles, and polyaromatics under mild conditions. This unprecedented class of (hetero)aryl-I-III compounds proved easy to purify, stable, and amenable to various synthetic transformations.
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