期刊
ANNALS OF NEUROLOGY
卷 82, 期 6, 页码 1016-1021出版社
WILEY
DOI: 10.1002/ana.25099
关键词
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资金
- Rosetrees Trust
- British Pharmacological Society
- Parkinson's UK [F-1202]
- MRC [G1100540, G0400074, G0502157, G0900652] Funding Source: UKRI
- Medical Research Council [G0502157, G0900652, G1100540, G0400074] Funding Source: researchfish
- Parkinson's UK [J-1402, F-1202] Funding Source: researchfish
In Parkinson disease (PD), mitochondrial dysfunction associates with nigral dopaminergic neuronal loss. Cholinergic neuronal loss co-occurs, particularly within a brainstem structure, the pedunculopontine nucleus (PPN). We isolated single cholinergic neurons from postmortem PPNs of aged controls and PD patients. Mitochondrial DNA (mtDNA) copy number and mtDNA deletions were increased significantly in PD patients compared to controls. Furthermore, compared to controls the PD patients had significantly more PPN cholinergic neurons containing mtDNA deletion levels exceeding 60%, a level associated with deleterious effects on oxidative phosphorylation. The current results differ from studies reporting mtDNA depletion in nigral dopaminergic neurons of PD patients. Ann Neurol 2017;82:1016-1021
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