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Membrane trafficking and remodeling at the host-parasite interface

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CURRENT OPINION IN MICROBIOLOGY
卷 40, 期 -, 页码 145-151

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CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.11.013

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资金

  1. Inserm
  2. CNRS
  3. University of Toulouse
  4. PIA PARAFRAP Consortium [ANR-11-LABX0024]
  5. PIA ANINFIMIP equipment [ANR-11-EQPX-0003]
  6. Idex Toulouse 'Attractivity Chair' Program

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Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host parasite cross-talk. Here, underscoring specificities and similarities between the T. gondii and Plasmodium contexts, we present recent findings about vacuolar membrane remodeling and its potential roles in parasite fitness and immune recognition. We review in particular the implication of tubulo-vesicular structures in trapping and/or transporting host and parasite components. Understanding how membrane remodeling influences host pathogen interactions is expected to be critical in the battle against many intracellular pathogens beyond parasites.

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