4.2 Article

Increased serum nonesterified fatty acid and low ionised calcium concentrations are associated with post partum colic in mares

期刊

EQUINE VETERINARY JOURNAL
卷 48, 期 1, 页码 39-44

出版社

WILEY-BLACKWELL
DOI: 10.1111/evj.12391

关键词

horse; nonesterified fatty acids; parturition; mare; calcium; colic

资金

  1. Morris Animal Foundation

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Reasons for performing studyIncreased serum nonesterified fatty acids (NEFA) and decreased serum electrolytes are linked to abdomasal displacements in post partum dairy cattle. Post partum colic in mares may be associated with metabolic changes specific to pregnancy and the periparturient period. ObjectivesTo determine if fluctuations in serum NEFA, ionised calcium (iCa) and magnesium (iMg) occurred in periparturient mares and if these alterations were associated with post partum colic. Study designLongitudinal observational study. MethodsMares from 3 farms in central Kentucky were enrolled. Blood samples were collected 14 days prior to the estimated foaling date, within 4 days post parturition, and 14 and 28 days after foaling for batch analysis of serum NEFA, iCa and iMg. Health information was provided by farm managers and veterinarians. Data were analysed using Kruskal-Wallis (2) statistic for nonparametric data and a matched case/control approach. Repeated measures logistic regression models were developed. ResultsSerum NEFAs were higher at 14-1 day before foaling (mean s.d., mmol/l), 0.28 +/- 0.12, P = 0.04 and from foaling to 4 days after foaling, 0.29 +/- 0.20 (P = 0.05) in mares that developed colic compared with those that did not colic, 0.19 +/- 0.05 and 0.21 +/- 0.14, respectively. Ionised calcium was lower at 15-28 days post foaling in mares that showed colic, 1.50 +/- 0.17 compared to mares that did not colic, 1.60 +/- 0.12, P = 0.02. Risk of colic in post partum mares increased 38% for each 0.1 mmol/l increase in serum NEFA (odds ratio = 1.38, 95% confidence interval 1.06-1.81, P = 0.02). ConclusionsMares with post partum colic had significantly higher serum NEFA and lower iCa prior to the colic episode compared with mares that did not develop colic. Monitoring these metabolic alterations may lead to predictive and preventive colic strategies for post partum mares.

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