期刊
CELLULAR IMMUNOLOGY
卷 321, 期 -, 页码 3-7出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2017.09.004
关键词
B cell; T-bet; TLR; IL21; IFN-gamma; Signalling
资金
- Intramural NIH HHS [ZIA AG000777-07, Z99 AG999999] Funding Source: Medline
Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with Age-associated B cells or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by interplay between various cytokines, notably, the TFH cytokines IL-21, IL-4 and IFN gamma. Adaptive signals by themselves cannot upregulate T-bet; however, they have a synergistic effect on induction of T-bet by innate receptors. The functional role of T-bet + B cells is unclear, although it is known that T-bet promotes class switching to IgG2a/c. It is likely T-bet serves dichotomous roles in B cells, promoting pathogenic autoreactive antibodies on one hand but mediating microbial immunity on the other, making it a target of interest in both therapeutic and prophylactic settings.
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