期刊
BIOMATERIALS
卷 143, 期 -, 页码 142-148出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.08.003
关键词
Biodegradable; Implantable; Elastomers; Optical fibers; Imaging
资金
- National Institutes of Health [NCI CA182670, NHLBI HL118498]
Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechanobiological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation. (C) 2017 Elsevier Ltd. All rights reserved.
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