Preparation and reactivity of sterically encumbered organocatalysts and their use in the preparation of (S)-Pregabalin precursors

Herein we describe the preparation of a new class of sterically demanding organocatalysts derived from D-fructose and their use, alongside hitherto unreported doubly quaternarised Cinchona ammonium salts, in the Michael reaction of nitromethane with 4-nitro-5-alkenyl-isoxazoles. (C) 2017 Elsevier Ltd. All rights reserved.