期刊
ADVANCES IN COLLOID AND INTERFACE SCIENCE
卷 249, 期 -, 页码 149-162出版社
ELSEVIER
DOI: 10.1016/j.cis.2017.05.011
关键词
Red blood cell; Atomic force microscopy; AFM; Immunohaematology; Force spectroscopy
资金
- Australian Research Council [LP110200973]
- Haemokinesis
- Australian Research Council [LP110200973] Funding Source: Australian Research Council
Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohae. matology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.
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