期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 95, 期 -, 页码 394-401出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.08.075
关键词
Cassia auriculata; Anti-hyperlipidemia; Triacylglycerol; Atorvastatin; Triton WR-1339
资金
- National Medicinal Plant Board (NMPB), Ministry of Ayush, India
Hyperlipidemia in the male albino Wistar rats was induced by Triton WR-1339. The treatment of the hyperlipidemic animals with the ethanol extract of Cassia auriculata flower (Et-CAF) exhibited a dose dependent reduction in serum triacylglycerol, total cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL) similar to the hyperlipidemic animals treated with standard drug atorvastatin. Hyperlipidemia altered the protein and mRNA expression levels of the key genes (SREBP-1c, ACC1, SREBP-2, HMGR, HMGS, CYP7A1, and ABCA1) in lipid metabolism and the treatment with Et-CAF (300 mg/kg b.wt) reverted these levels similar to that observed with atorvastatin treated hyperlipidemic animals. These results revealed that Et-CAF extract served as an efficient anti-hyperlipidemic drug.
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