Manganese-proline derived new catalyst system for the enantioselective synthesis of α-hydroxyphosphonates and α-aminophosphonates

A novel manganese/proline-derived catalyst system is reported for the stereoselective synthesis of alpha-hydroxyphosphonates and alpha-aminophosphonates. The reaction proceeded smoothly under mild reaction conditions with efficient reaction times. The resulting products were obtained with high yields and good enantioselectivities (up to 83% ee). (C) 2017 Elsevier Ltd. All rights reserved.