Copper(II)-mediated o-arylation of 3-hydroxy-2-oxindoles with boronic acids at room temperature

Synthesis of 3-aryloxy-2-oxindole derivatives from 3-hydroxy-2-oxindoles and aryl boronic acids through copper(II)-promoted reaction is achieved. This reaction provides an efficient protocol for the coupling between aryl boronic acid and tertiary aliphatic alcohol, opening a new avenue to format corresponding 3-phenyl-3-aryloxy-2-oxindole core, which has potentially value in the field of life-science. (C) 2017 Elsevier Ltd. All rights reserved.