Efficient one-pot synthesis of 1,3-dihydro-2H-pyrrol-2-one derivatives via aza-oxyallylic cations

An efficient synthesis of functionalized 1,3-dihydro-2H-pyrrol-2-one was developed based on a [3+2] cycloaddition reaction of aza-oxyallylic cations and alkynes. With this novel method, a variety of substituted alkynes were readily converted into their corresponding pyrrolidinone analogues at room temperature. The protocol features easy operation, ambient temperature, good yields, readily available starting materials, and broad functional group tolerance. (C) 2017 Elsevier Ltd. All rights reserved.