Organocatalytic enantioselective Michael reaction of 1,3-dicarbonyls with α-substituted β-nitroacrylates

An efficient asymmetric Michael reaction of 1,3-dicarbonyl compounds with alpha-Substituted-beta-Nitro-acrylates has been developed by using a cinchona-thiourea bifunctional organocatalyst in high yields and enantioselectivies. One of adducts could be transformed into a chiral 1i-nitroester bearing an isoxazole skeleton and an all-carbon quaternary chiral center. (C) 2016 Elsevier Ltd. All rights reserved.