期刊
TETRAHEDRON
卷 73, 期 52, 页码 7308-7314出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.11.026
关键词
N-heterocyclic carbene-palladium complex; Amines; Aryl chlorides; C-N coupling; Synthetic method
资金
- National Natural Science Foundation of China [21471115]
Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes. (C) 2017 Elsevier Ltd. All rights reserved.
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