期刊
TETRAHEDRON
卷 73, 期 2, 页码 164-171出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.11.067
关键词
Urea-catalyzed; Pyrano[2,3-c]pyrazole; Multi-component reaction; One-pot synthesis
资金
- National Natural Science Foundation of China [21462041]
- Natural Science Foundation for Distinguished Young Scholars of Xinjiang Uyghur Autonomous Region [Qn2015jq002]
- Tianshan Talent Cultivation Project of Xinjiang Uyghur Autonomous Region
A facile one-pot, multicomponent protocol for the synthesis of 1,4-dihydro-pyrano[2,3-c]pyrazole derivatives using a urea catalyst is reported. This transformation proceeds via a four-component reaction of ethyl acetoacetate, a hydrazine, 3-oxo-pentanedioic acid dimethyl ester, and malononitrile. The bifunctional nature of urea means that it catalyzes many steps in this transformation, including domino Knoevenagel condensation, Michael addition, and ring opening and closing reactions. This synthetic method has several advantages, including good yield, simple work-up, harmless by-products, and simple purification. (C) 2016 Elsevier Ltd. All rights reserved.
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