期刊
TETRAHEDRON
卷 73, 期 52, 页码 7245-7253出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.11.001
关键词
Isoindolinone; Aromatic imine; Lithiation; Carbon monoxide; Fungicidal activity
资金
- National Key Research and Development Plan of China [2017YFD0200903]
- Natural Science Fund of Tianjin, China [14JCYBJC19700]
A simple and convenient one-pot synthesis of 3-acyl, methylene and epoxy isoindolinone derivatives via the reaction of o-lithiated aromatic imines with carbon monoxide followed with acyl chlorides or PhCO(CH2)(n)Br (n = 1 or 3) under mild reaction conditions has been developed. Preliminary in vitro tests for fungicidal activity of these isoindolinone derivatives indicated that most of them exhibit good fungicidal activity against Sclerotinia sclerotiorum. (C) 2017 Elsevier Ltd. All rights reserved.
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