期刊
TETRAHEDRON
卷 73, 期 20, 页码 2943-2948出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.04.002
关键词
Cobalt; Oxidative esterification; C(sp(3))-H bond activation; Carboxylic acid; Peroxide
资金
- National Key Projects for Fundamental Research and Development of China [2016YFB0601303]
- National Natural Science Foundation of China [21476240]
- Key Program of National Natural Science Foundation of China [91434203]
- Instrument Developing Project of the Chinese Academy of Sciences [YZ201521]
- CAS (Chinese Academy of Sciences) 100-Talent Program
A protocol for the cobalt-catalyzed oxidative esterification of allylic/benzylic C(sp(3))-H bonds with carboxylic acids was developed in this work. Mechanistic studies revealed that C(sp(3))-H bond activation in the hydrocarbon was the turnover-limiting step and the in-situ formed [Co(III)]Ot-Bu did not engage in hydrogen atom abstraction (HAA) of a C H bond. This protocol was successfully incorporated into a synthetic pathway to beta-damascenone that avoided the use of NBS. (C) 2017 Elsevier Ltd. All rights reserved.
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