期刊
JOURNAL OF MEDICAL IMAGING
卷 4, 期 4, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JMI.4.4.047501
关键词
cytology; feature analysis; chromatin distribution; cervical cancer; stepwise support vector machine
资金
- Saitama Medical University
- SMUFHMC
- Grants-in-Aid for Scientific Research [15K20899] Funding Source: KAKEN
Cytology, a method of estimating cancer or cellular atypia from microscopic images of scraped specimens, is used according to the pathologist's experience to diagnose cases based on the degree of structural changes and atypia. Several methods of cell feature quantification, including nuclear size, nuclear shape, cytoplasm size, and chromatin texture, have been studied. We focus on chromatin distribution in the cell nucleus and propose new feature values that indicate the chromatin complexity, spreading, and bias, including convex hull ratio on multiple binary images, intensity distribution from the gravity center, and tangential component intensity and texture biases. The characteristics and cellular classification accuracies of the proposed features were verified through experiments using cervical smear samples, for which clear nuclear morphologic diagnostic criteria are available. In this experiment, we also used a stepwise support vector machine to create a machine learning model and a cross-validation algorithm with which to derive identification accuracy. Our results demonstrate the effectiveness of our proposed feature values. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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