期刊
TETRAHEDRON
卷 73, 期 24, 页码 3377-3386出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.05.015
关键词
[1,4]Diazepine; Racemate; Cyclization; Molecular docking; Receptor
资金
- National Science Center (PRELUDIUM) [2015/17/N/ST5/01973]
- National Science Center [2016/20/T/ST5/00187]
- Adam Mickiewicz University Foundation in Poznan
An efficient one-pot strategy for the synthesis of a new family of imidazo[1,4]diazepines has been developed and its mechanism has been proposed, which follows a seven-membered ring closure reaction. The condensation of 2- and 4-imidazolecarboxaldehyde with pyrazole amines provides six compounds 1-6, which are based on two types of fused tricyclic scaffolds. All presented compounds were fully spectroscopically characterized and their structure was unambiguously determined by single crystal X-ray crystallography. Molecular docking studies reveal a high similarity between binding modes of diazepines 1, 6 and eticlopride in the dopamine D-3 receptor, as well as between enantiomers 2S, 6S and nortriptyline in dopamine transporter DAT. (C) 2017 Elsevier Ltd. All rights reserved.
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