Nucleophilic disulfurating reagents for unsymmetrical disulfides construction via copper-catalyzed oxidative cross coupling

Novel disulfuration was established via cross coupling between nucleophilic disulfurating reagent and arylsilane introducing two sulfur atoms in one step. This methodology was applied to synthesize various unsymmetrical disulfides under mild conditions via copper-catalyzed oxidative Hiyama-type cross coupling, providing a new pathway for disulfide synthesis. In addition, pH value of system displayed a key role in alcoholysis process. (C) 2017 Elsevier Ltd. All rights reserved.