期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 44, 期 2, 页码 479-493出版社
KARGER
DOI: 10.1159/000485085
关键词
Retinitis pigmentosa; Curcumin; Microglia; rd1 mice; Visual function
资金
- National Natural Science Foundation of China [31271051, 81570890]
- Foundation of Southwest Hospital [SWH2016LHYS-03, SWH2016JG021]
Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease. Methods: Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice. Results: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retinaderived 661W cells. Conclusions: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP. (C) 2017 The Author(s) Published by S. Karger AG, Basel
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