期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 159, 期 -, 页码 580-585出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2017.08.028
关键词
Progesterone; Oral bioavailability; Chitosan; Cholesterol-free liposomes
资金
- National Natural Science Foundation of China [81460539]
- Excellent Young Researchers Project in Xinjiang Autonomous Innovation Project [qn2015yx018]
Based on the structurally similar properties of progesterone and cholesterol, chitosan-coated cholesterol free liposomes (CS-Lipo/Prog) were formulated. CS-Lipo/Prog are spherical and uniform in size (662.1 +/- 19.3 nm) with positive potential (28.19 +/- 1.97 mV). The average drug entrapment efficiency (EE) is approximately 80%. The in vitro release profile of CS-Lipo/Prog shows sustained release. The in vitro stability evaluation demonstrated that CS-Lipo/Prog can efficiently shield Prog from degradation in the gastrointestinal tract. CS-Lipo/Prog showed a longer MRT and higher AUC(0-infinite) after oral administration to mice than in the control group (progesterone-free). The relative bioavailability of CS-Lipo/Prog was higher than that of progesterone soft capsules (QINING (R)) and Lipo/Prog. Collectively, these findings suggest that cholesterol-free chitosan-coated liposomes are a promising alternative for improving the oral bioavailability of progesterone. (C) 2017 Elsevier B.V. All rights reserved.
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