期刊
TALANTA
卷 165, 期 -, 页码 176-181出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.11.036
关键词
Deep eutectic solvent; Air assisted emulsification liquid-liquid microextraction; Methadone; Biological samples
资金
- research council of faculty of pharmacy, Tehran University of medical sciences
Nowadays, a deep eutectic solvent (DES) has recently been considered as a green ion liquid analogue. In this study, a new compound of DES has been synthesized as an extraction solvent in air assistedemulsification liquid-liquid microextraction method (DES-AAELLME) for preconcentration and extraction of methadone followed by gas chromatographyflame ionization detector (GC-FID). To obtain an efficient water-miscible deep eutectic solvent, choline chloride (ch-cl) and 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalen-2-ol (TNO) were mixed at a molar ratio of 1:2 and tetrahydrofuran (THF) was used as a demulsifier solvent into homogeneous solution for providing a turbid state. The solution was rapidly sucked up and injected 10 times using a 10-mL glass syringe to enhance the turbidity of solution and disperse the aggregated DES droplets into aqueous phase. Some important parameters affecting extraction recovery were investigated. Under optimum conditions, the calibration curve was linear in the concentration range from 2 to 8000 mu g L-1. The limit of detection and the limit of quantification were found 0.7 mu g L-1 and 2.3 mu g L-1 respectively with preconcentration factor of 270. The precision, as the relative standard deviation (RSD) (n=6), was < 6% respectively. This method was successfully applied to determine methadone in water and biological samples with an appropriate recovery about 98.4-101.2%.
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