期刊
TALANTA
卷 175, 期 -, 页码 477-482出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2017.07.067
关键词
MOF; Glycopeptide enrichment; Hydrophilicity; Binary ligands
资金
- National Natural Science Foundation of China [21425518, 21405022, 21675034]
- National Basic Research Priorities Program of China [2013CB911201]
Highly efficient and selective enrichment of glycopeptides from complex biosamples is vital prior to mass spectrometry analysis. In this work, a hydrophilic metal organic framework with free carboxylic groups (denoted as Ui0-66-COOH) was synthesized in one step with binary ligands. Compared with pure UiO-66 with one ligand, Ui0-66-COOH containing binary ligands demonstrated greater hydrophilicity and performed much better in selective enrichment of glycopeptides. The as-prepared material demonstrated excellent performance for selective enrichment of glycopeptides from tryptic digests of standard glycoproteins and practical biological samples.
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