期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 31, 期 6, 页码 535-546出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2017.11.001
关键词
neurohypophysis; osmoregulation; suprachiasmatic nucleus; supraoptic nucleus; thirst; vasopressin
资金
- Foundation Grant from the Canadian Institutes of Health Research (CIHR) [FDN 143337]
- Heart and Stroke Foundation of Canada [G-16-00014197]
- James McGill Chair
- Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Award
- Fonds de Recherche Quebec Sante
Vasopressin is a neuropeptide synthesized by specific subsets of neurons within the eye and brain. Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney. Moreover vasopressin is a neurotransmitter and neuromodulator that contributes to time-keeping within the master circadian clock (i.e. the suprachiasmatic nucleus, SCN) and is also used as an output signal by SCN neurons to direct centrally mediated circadian rhythms. In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep. (C) 2017 Elsevier Ltd. All rights reserved.
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