期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 50, 页码 44114-44123出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14772
关键词
magnetic nanoparticles; molecular imprinting polymers; photoresponsive materials; solid-phase extraction; paracetamol sensing
资金
- National Natural Science Foundation of China [21475046, 21427809, 21645004]
- State Key Laboratory of Pulp and Paper Engineering [201623]
- Fundamental Research Funds for the Central Universities [2015ZP028, 2017MS094]
Herein, a novel photoresponsive magnetic electrochemical imprinting sensor for the selective extraction of paracetamol from biological samples was designed. In particular, nanosized photoresponsive molecular imprinted polymers were prepared on the surface of magnetic Fe3O4 nanoparticles through living radical polymerization of azobenzene. The introduction of a magnetic-controlled glassy carbon electrode makes the immobilization and removal of nanosized photoresponsive molecular imprinted polymers on the magnetic-controlled glassy carbon electrode surface facilely operational. With the photoresponsive property, the sensor undergoes reversible release and uptake of paracetamol upon alternative irradiation at 365 and 440 nm basing on a configurational change of azobenzene monomer in the photoresponsive molecular imprinted polymers receptor sites. Simultaneously, these processes are monitored by the photoresponsive changes of electrochemical signal from paracetamol. Two linear ranges from 0.001 to 0.7 mmol L-1 (R-2 = 0.96) and 0.7 to 7 mmol L-1 (R-2 = 0.95) for paracetamol determination were obtained with a quantification limit of 0.000 86 mmol L-1 and a detection limit of 0.000 43 mmol L-1. The recoveries of paracetamol in the urine as determined by photoresponsive molecular imprinted polymers extraction were varied between 87.5% and 93.3%. As a consequence, combining photocontrolled selective extraction, interfacial stability from magnetic adsorption, and specifically electrochemical response, the photoresponsive molecular imprinted polymers sensor shows significant advantages for simultaneous separation, enrichment, and detection of trace paracetamol in biological samples.
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