4.3 Article

Short eight-steps total synthesis of racemic asteriscunolide C

期刊

SYNTHETIC COMMUNICATIONS
卷 47, 期 22, 页码 2103-2108

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2017.1365907

关键词

Asteriscunolides; Horner-Wittig-Emmons; macrolide; racemic synthesis; ring-closing metathesis

资金

  1. Board of Research in Nuclear Sciences [2013/37C/59/BRNS/2443]

向作者/读者索取更多资源

A concise total synthesis of racemic asteriscunolide C in eight steps has been described starting from neopentane diol involving an efficient Yamaguchi esterification using an aldehyde-acid, intramolecular Horner-Wittig-Emmons olefination, and a late stage ring-closing metathesis to construct the strained 11-membered ring with one Z- and two E-double bonds.

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