期刊
SYNTHESIS-STUTTGART
卷 49, 期 12, 页码 2589-2604出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589491
关键词
piperazine; heterocycle; synthesis; cyclization; catalysis
资金
- Purdue University
- Purdue Center for Cancer Research
Piperazine ranks as the third most common N-heterocycle appearing in small-molecule pharmaceuticals. This review highlights recent advances in methods development for the construction of the piperazine ring system with particular emphasis on preparing carbon-substituted piperazines.
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