期刊
SYNTHESIS-STUTTGART
卷 49, 期 22, 页码 4978-4985出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588527
关键词
trifluoromethylation; photoredox catalysis; continuous flow; Langlois reagent; visible light
资金
- European Union for a Marie Curie ITN [64186]
- VIDI grant [14150]
We report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF3)ppy}(2)](dtbpy)]PF6 as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.
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