期刊
SYNTHESIS-STUTTGART
卷 49, 期 21, 页码 4753-4758出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588811
关键词
allylic substitution; copper; homoallylic boronates; hydrocupration; N-heterocyclic carbenes; tandem reaction
资金
- National Research Foundation of Korea - Korean government (MEST) [NRF-2016R1A2B4011719]
A tandem hydrocupration/allylation of alkenyl boronates efficiently proceeds with NHC-copper catalysts using hydrosilane and allyl phosphate as reagents. In the presence of IMes-Cu catalyst, the allylation of in situ generated B--copper intermediates smoothly occurs to give homoallylic boronates in high yields, despite competitive side reaction pathways. Mono- and disubstituted alkenyl boronates were effective in the reaction with terminal allyl phosphates, but trisubstituted substrates showed limited reactivity.
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