Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

This short review provides an overview concerning the developments toward the catalytic enantioselective syntheses of isoxazolidin-5-one derivatives making use of metal-based or organocatalytic conditions. The subsequent use and chemical transformations of these valuable chiral oxazole heterocycles will also be described. 1 Introduction 2 Aza-Michael Strategy 3 Nitroso-Based Annulation Strategy 4 Nitrone-Based Annulation Strategy 5 Functionalization Reactions of Isoxazolidin-5-ones 6 Miscellaneous 7 Conclusion