期刊
SYNTHESIS-STUTTGART
卷 49, 期 17, 页码 3905-3915出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1590502
关键词
Werner complexes; cobalt; 1,2-diamine ligands; chiral-at-metal complexes; hydrogen bonding; enantioselective catalysis; chiral benzylic amines; lipophilic anions
资金
- Welch Foundation [A-1656]
The enantiopure salt Delta-[Co((S,S)-dpen)(3)](3+) 2Cl(-)BAr(f)(-)[BArf = B(3,5-C6H3(CF3)(2))(4)] is an effective hydrogen bond donor catalyst (10 mol%, r.t., CH2Cl2) for enantioselective additions of dialkyl malonates to Boc-derivatized aryl imines generated from sulfones [ArCH(SO2Ph)NHBoc] in the presence of K2CO3 (ten examples, 91-97% isolated yields, 87-99% ee). The diastereomeric salt Lambda-[Co((S,S)-dpen)(3)](3+) 2Cl(-)BAr(f20) [BArf20- = B(C6F5)(4)(-)] is similarly applied to additions of nitroalkanes (four examples, 89-93% isolated yields, 79-91% ee). Precautions to exclude air or moisture are unnecessary.
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