期刊
SYNTHESIS-STUTTGART
卷 50, 期 1, 页码 146-154出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589100
关键词
homocoupling; electrochemistry; biaryl compounds; nickel; catalysis
资金
- CNRS
- Universite Paris-Est Creteil
Due to their widespread presence in functional materials and pharmaceuticals, biaryls are of fundamental importance in organic chemistry. Methods for the synthesis of symmetrical biaryls generally involve both metallic reduction and transition-metal catalysis. In this work, we show that electroreduction can also constitute a very relevant way to achieve the nickel-catalyzed reductive synthesis of symmetrical biaryl compounds. Therefore, it is demonstrated that both aryl and heteroaryl halides undergo reductive coupling to furnish the corresponding symmetrical biaryls in fair to excellent yields. Reactions are performed under very mild conditions thus ensuring important functional group tolerance.
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